Use mRNA to design new drug against Zika virus.
The tertiary structural information can help to development of new drugs for this virus The cryoEM structure map with 3.7 Angestrom resolution (PDBid=5ire) reconstructed and this map showed well-resolved densities corresponding to the α-helices and β-strands. This virus have 180 copies of each of E and M proteins on its surface, there are some transmembrane region in this protein for their anchoring in the lipid membrane. The role of the E protein is in fusion receptor binding and composed of three ectodomain (D1, D2, and D3). Antibodies design against of this virus target epitops in this ectodomains. The M protein is hidden in hidden under the E protein. In this study, Justin M. Richner and et al developed a vaccine platfom in which lipid nanoprticle encapsulate modified mRNA encoding wild-type or variant ZIKV structural genes.