EMT (Epithelial-to-mesenchymal transition)

Uncontrolled cellular proliferation is a hallmark of cancer and New cells grow even when you don't need them, and old cells don't die when they should. TGF-beta families are one of the few classes of endogenous inhibitors of cell growth. The epithelial–mesenchymal transition (EMT) is a process that epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced intercellular tight junctions and increased motility.

A critical molecular feature of EMT is the downregulation of E-cadherin, a cell adhesion molecule present in the plasma membrane of most normal epithelial cells. One of the best known inducers of EMT in cultured epithelial cells is transforming growth factor-b (TGFb), which, paradoxically, is known to be a growth suppressor in non-neoplastic epithelium but a tumor promoter in advanced cancers. in this paper David et al showed that how TGF-b-induced EMT is coupled to either apoptosis or tumor progression.

Wednesday 15 February 2017